Background: Herbal medicines have long been used for various ailments in various societies and natural bioactive\ncompounds are gaining more and more importance due to various factors. In this context, three plant species i.e.,\nEryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific\nverification of their purported traditional uses against various infectious diseases.\nMethods: In this study, three plants were assayed for antibacterial and antifungal potentials. The antibacterial\ninvestigations were performed via well diffusion method and nutrient broth dilution method. The bacterial\nstrains used in the study were Enterococcus faecalis, Proteus mirabilis, Escherichia coli, Salmonella typhi, Klebsiella\npneumonia and Pseudomonas aeruginosa. The antifungal potential was investigated by dilution method of\nMuller-Hinton agar media of the plantsâ�� samples. The fungal strains used were Aspergillis fumigatus, Aspergillis\nflavus and Aspergillis niger. Ceftriaxone and nystatin were used as standard drugs in antibacterial and antifungal assays\nrespectively.\nResults: Different fractions from N. thomsonianum were tested against five bacterial strains while the samples from A.\nconsanguineum and E. caeruleum were tested against six bacterial strains. All the samples exhibited prominent\nantibacterial activity against the tested strains. Overall, chloroform and ethyl acetate fractions were found most\npotent among the three plantsâ�� samples. N. thomsonianum excelled among the three plants in antibacterial\nactivity. Similarly, in antifungal assay, N. thomsonianum exhibited strong antifungal activity against the fungal\nstrains. The chloroform fraction displayed MFCs of 175.67 �± 5.20***, 29.33 �± 5.48*** and 63.00 �± 4.93*** �¼g/ml\nagainst Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger respectively. The whole study demonstrates\nthat all the three plant species were active against tested bacterial and fungal strains.\nConclusion: It can be concluded from our findings that N. thomsonianum, A. consanguineum and E. caeruleum\nhave broad antibacterial and antifungal potentials. In all of the plantsâ�� samples, chloroform and ethyl acetate\nfractions were more active. Furthermore, being the potent samples, the chloroform and ethyl acetate fractions\nof these plants can be subjected to column chromatography for the isolation of more effective antimicrobial\ndrugs.
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